2024

133. Q. Chen, J. Diao. Super-resolution imaging of sub-cellular dynamics of drug molecules. Adv. Drug Deliv. Rev.  (2024).

132. K. Qiu, X. Xu, K. Zhang, J. Diao. Alternating cellular functions by optogenetic control of organelles. Methods Mol. Biol.  (2024).

131. C. Wang, C. Zhao, X. Hu, J. Qiang, Z. Liu, J. Gu, S. Zhang, D. Li, Y. Zhang, J. Burré, J. Diao, C. Liu. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine. eLife 13, RP97228 (2024).

130. J. Diao. Q&A with Jiajie Diao. Cell Rep. 43, 113741 (2024).

129. J. Diao, C.K. Yip, Q. Zhong. Recent advances in the molecular structures and function of the autophagosome-lysosome fusion machinery. Autophagy Rep. 3, 2305594 (2024).

128. M. Xue, L. Dong, H. Zhang, Y. Li, K. Qiu, Z. Zhao, M. Gao, L. Han, A.K.N. Chan, W. Li, K. Leung, K. Wang, S.P. Pokharel, Y. Qing, W. Liu, X. Wang, L. Ren, H. Bi, L. Yang, C. Shen, Z. Chen, L. Melstrom, H. Li, N. Timchenko, X. Deng, W. Huang, S.T. Rosen, J. Tian, Lin Xu, J Diao, C.-W. Chen, J. Chen, B. Shen, H. Chen, R. Su. METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation. J. Hematol. Oncol. 17, 7 (2024).

127. M. Wu, Y. Xiang, L. Tang, W. Li, X. Wang, Y. Du, W. Zuo, S. Zhang, Q. Hu, M. Wang, J. Diao, J. Wu, Y. Lai. Molecular imaging of aging-related 5-hydroxymethylcytosine in cell-free DNA at the single-copy level. Sens. Actuator B-Chem. 402, 135098 (2024).

2023

126. Q. Chen, L.-Y. Liu, Z. Tian, Z. Fang, K.-N. Wang, H. Chen, X. Shao, C. Zhang, W. Zou, F. Rowan, K. Qiu, B. Ji, J.-L. Guan, D. Li, Z.-W. Mao, J. Diao. Mitochondrial nucleoid condensates induce peripheral fission through high membrane curvature. Cell Rep. 42, 113472 (2023).

125. Y. Lai, C. Zhao, Z. Tian, C. Wang, J. Fan, X. Hu, J. Tu, T. Li, J. Leitz, R.A. Pfuetzner, Z. Liu, S. Zhang, Z. Su, J. Burré, D. Li, T.C. Südhof, Z.-J. Zhu, C. Liu, A.T. Brunger, J. Diao. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering. Proc. Natl. Acad. Sci. USA 120, e2310174120 (2023).

124. X. Xu, K. Qiu, Z. Tian, C. Aryal, F. Rowan, R. Chen, Y. Sun, J. Diao. Probing the dynamic crosstalk of lysosomes and mitochondria with structured illumination microscopy. TrAC Trends Anal. Chem. 169, 117370 (2023).

123. O. Tyoe, C. Aryal, J. Diao. Docosahexaenoic acid promotes vesicle clustering mediated by alpha-Synuclein via electrostatic interaction. Eur. Phys. J. E 46, 96 (2023).

122. R. Chen, K. Qiu, B.K. Kundu, G. Ding, G. Han, Y. Sun, J. Diao. Quantifying cell viability through organelle ratiometric probing. Chem. Sci. 14, 10236 (2023). Highlighted by: UC News 

121. R. Chen, K. Qiu, D.C.Y. Leong, B.K. Kundu, C. Zhang, P. Srivastava, K.E. White, G. Han, Z. Guo, C.G. Elles, J. Diao, Y. Sun. A general design of pyridinium-based fluorescent probes for enhancing two-photon microscopy. Biosens. Bioelectron. 239, 115604 (2023). Highlighted by: UC News 

120. Y. Wang, Y.-S. Chan, M. Chae, D. Shi, C.-Y. Lee, J. Diao. Programmable digital-microfluidic biochips for SARS-CoV-2 detection. Bioengineering 10, 923 (2023).

119. X. Shao, Z. Fang, M. Li, W. Zou, Q. Wang, C. Zhang, Y. Wei, Z. Tian, Y. Lai, Y. Cao, B. Ji, D. Li, Q. Chen, J. Diao. Graphene oxide nanosheets induce mitochondrial fragmentation by cutting through membrane. ACS Mater. Lett. 5, 2308 (2023).

118. C. Zhang, Z. Tian, R. Chen, F. Rowan, K. Qiu, Y. Sun, J.-L. Guan, J. Diao. Advanced imaging techniques for tracking drug dynamics at the subcellular level. Adv. Drug Deliv. Rev. 199, 114987 (2023).

117. R. Chen, L. Wang, G. Ding, G. Han, K. Qiu, Y. Sun, J. Diao. A constant conversion rate of endolysosomes revealed by a pH-sensitive fluorescent probe. ACS Sensors 8, 2068 (2023). Highlighted by: UC News

116. K. Qiu, Z. Tian, J. Diao. Monitoring lysosomal acidity. Nat. Chem. Biol. 19, 1434 (2023).

115. B. Bu, Z. Tian, D. Li, K. Zhang, W. Chen, B. Ji, J. Diao. Double-transmembrane domain of SNAREs decelerates the fusion by increasing the protein-lipid mismatch. J. Mol. Biol. 435, 168089 (2023).

114. K. Qiu, W. Zou, Z. Fang, Y. Wang, S. Bell, X. Zhang, Z. Tian, X. Xu, B. Ji, D. Li, T. Huang, J. Diao. 2D MoS2 and BN nanosheets damage mitochondria through membrane penetration. ACS Nano 17, 4716 (2023).

113. Y.-S. Chan, J. Diao, C.-Y. Lee. A pattern-control digital microfluidic bio-chip for fast thermal cycle in medical tests. 2023 IEEE International Symposium on Circuits and Systems (ISCAS), Monterey, CA, USA, 2023, pp. 1-4, doi: 10.1109/ISCAS46773.2023.10181466.

112. D. Li, J. Diao. Protein-membrane interaction at the pre-synapse. J. Mol. Biol. 435, 167905 (2023).

111. H. Fang, L. Hu, Q. Chen, S. Geng, C. Wang, M. Hao, Z. Tian, H. Chen, L. Liu, J.-L. Guan, Y. Chen, L. Dong, Z. Guo, W. He, J. Diao. An ER-targeted “reserve-release” fluorogen for topological quantification of reticulophagy. Biomaterials 292, 121929 (2023).

2022

110. K. Wu, W. Sun, D. Li, J. Diao, P. Xiu. Inhibition of amyloid nucleation by steric hindrance. J. Phys. Chem. B 126, 10045 (2022).

109. D.G. Gamage, K. Melikov, P. Munoz-Tello, T. Wherley, L. Focke, E. Leikina, E. Huffman, J. Diao, D.J. Kojetin, V. Prasad, L.V. Chernomordik, D.P. Millay. Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion. Proc. Natl. Acad. Sci. USA 119, e2202490119 (2022).

108. K. Qiu, A. Yadav, Z. Tian, Z. Guo, D. Shi, C.K. Nandi, J. Diao. Ultra-long-term super-resolution tracking of lysosomes in brain organoids by near-infrared noble metal nanoclusters. ACS Mater. Lett. 4, 1565 (2022).

107. K. Qiu, W. Zou, H. Fang, M. Hao, K. Mehta, Z. Tian, J.-L. Guan, K. Zhang, T. Huang, J. Diao. Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts. Nat. Commun. 13, 4303 (2022). Highlighted by: UC News 

106. G. Fang, H. Chen, X. Shao, H. Wang, D. Zhan, R. Wang, P. Meng, H. Fang, F. Liu, P. Ling, Z. Wu, J. Diao, Q. Yao, Q. Chen. Single image capture of bioactive ion crosstalk within inter-organelle membrane contacts at nanometer resolution. Small Methods 6, 2200321 (2022).

105. L. Wang, R. Chen, G. Han, X. Liu, T. Huang, J. Diao, Y. Sun. Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe. Exploration 2, 0210215 (2022).

104. Y. Wang, X. Hu, J. Long, J. Diao. Epigenetic optical sensing of 5-hydroxymethylcytosine at the single-molecule level. Sens. Actuator B-Chem. 358, 131500 (2022).

103. L. Wang, J. Diao. VAMP8 phosphorylation regulates lysosome dynamics in autophagy. Autophagy Rep. 1, 79 (2022).

102. K. Qiu, R. Seino, G. Han, M. Ishiyama, Y. Ueno, Z. Tian, Y. Sun, J. Diao. De novo design of a membrane-anchored probe for multi-dimensional quantification of endocytic dynamics. Adv. Healthc. Mater. 11, 2102185 (2022). Highlighted by: UC News

2021

101. C.M. Aryal, O. Tyoe, J. Diao. Lipid species dependent vesicles clustering caused by alpha-synuclein as revealed by single-vesicle imaging with total internal reflection fluorescence microscopy. Biophys. Rep. 7, 437 (2021).

100. Q. Chen, M. Hao, L. Wang, L. Li, Y. Chen, X. Shao, Z. Tian, R.A. Pfuetzner, Q. Zhong, A.T. Brunger, J.-L. Guan, J. Diao. Prefused lysosomes cluster on autophagosomes regulated by VAMP8. Cell Death Dis. 12, 939 (2021). 

99. J. Yan, Y. Wang, X. Li, D. Guo, Z. Zhao, G. Bai, J. Li, N. Huang, J. Diao, Y. Li, W. He, W. Liu, K. Tao. A bionic nano band-aid constructed by a three-stage self-assembly of peptides for rapid liver hemostasis. Nano Lett. 21, 7166 (2021).

98. K.-N. Wang, X. Shao, Z. Tian, L.-Y. Liu, C. Zhang, C.-P. Tan, J. Zhang, P. Ling, F. Liu, Q. Chen, J. Diao, Z.-W. Mao. A continuously add-on probe reveals a nonlinear enlargement of mitochondria in light-activated oncosis. Adv. Sci. 8, 2004566 (2021).

97. W. Zou, Q. Chen, J. Slone, L. Yang, X. Lou, J. Diao, T. Huang. Nanoscopic quantification of sub-mitochondrial morphology, mitophagy and mitochondrial dynamics in living cells derived from patients with mitochondrial diseases. J. Nanobiotechnol. 19, 136 (2021).

96. X. Zheng, J. Yan, W. You, F. Li, J. Diao, W. He, Y. Yao. De novo nano-erythrocyte structurally braced by biomimetic Au(I)-peptide skeleton for MDM2/MDMX predation towards augmented pulmonary adenocarcinoma immunotherapy. Small 17, 2100394 (2021).

95. Y. Du, Y. Lai, J. Liu, J. Diao. Epigenetic quantification of DNA 5-hydroxymethylcytosine using DNA hybridization-based single-molecule immunofluorescent imaging. Small Methods 5, 2100061 (2021).

94. Y. Tao, J. Xie, Q. Zhong, Y. Wang, S. Zhang, F. Luo, F. Wen, J. Xie, J. Zhao, X. Sun, H. Long, J. Ma, Q. Zhang, J. Long, X. Fang, Y. Lu, D. Li, M. Li, J. Zhu, B. Sun, G. Li, J. Diao, C. Liu. A novel partially-open state of SHP2 points to a “multiple gear” regulation mechanism. J. Biol. Chem. 296, 100538 (2021).

93. E. Lerner et al. FRET-Based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices. Elife 10, e60416 (2021).

92. D.J. Klionsky et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17, 1  (2021). 

91. J. Liu, B. Bu, M. Crowe, D. Li, J. Diao, B. Ji. Membrane packing defects in synaptic vesicles recruit complexin and synuclein. Phys. Chem. Chem. Phys. 23, 2117 (2021).

90. H. Fang, S. Geng, M. Hao, Q. Chen, M. Liu, C. Liu, Z. Tian, C. Wang, T. Takebe, J.-L. Guan, Y. Chen, Z. Guo, W. He, J. Diao. Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells. Nat. Commun. 12, 109 (2021).