89. Q. Chen, H. Fang, X. Shao, Z. Tian, S. Geng, Y. Zhang, H. Fan, P. Xiang, J. Zhang, X. Tian, K. Zhang, W. He, Z. Guo, J. Diao. A dual-labeling molecular probe to track functional mitochondria-lysosome interactions in live cells. Nat. Commun. 11, 6290 (2020).

88. K. Wu, D. Li, P. Xiu, B. Ji, J. Diao. O-GlcNAcylation inhibits the oligomerization of alpha-synuclein by declining intermolecular hydrogen bonds through a steric effect. Phys. Biol. 18, 016002 (2020).

87. L.-Y. Liu, H. Fang, Q. Chen, M. H.-Y. Chan, M. Ng, K.-N. Wang, W. Liu, Z. Tian, J. Diao, Z.-W. Mao, V. W.-W. Yam. Multiple-color platinum complex with super-large Stokes shift for super-resolution imaging of autolysosome escape. Angew. Chem. Int. Ed. 59, 19229 (2020).

86. M. Li, T.-J. Oh, H. Fan, J. Diao, K. Zhang. Syntaxin clustering and optogenetic control for synaptic membrane fusion. J. Mol. Biol. 432, 4773 (2020).

85. K. Qiu, Y. Du, J. Liu, J.-L. Guan, H. Chao, J. Diao. Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles. Theranostics 10, 6072 (2020).

84. X. Shao, Q. Chen, L. Hu, Z. Tian, L. Liu, F. Liu, F. Wang, P. Ling, Z.-W. Mao, J. Diao. Super-resolution quantification of nanoscale damage to mitochondria in live cells. Nano Res. 13, 2149 (2020).

83. Q. Chen, X. Shao, M. Hao, R. Guan, Z. Tian, M. Li, C. Wang, L. Ji, H. Chao, J.-L. Guan, J. Diao. Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy. Biomaterials 250, 120059 (2020).

82. J. Sun, K. Du, J. Diao, X. Cai, F. Feng, S. Wang. GSH and H2O2 co-activatable mitochondria-targeted photodynamic therapy under normoxia and hypoxia. Angew. Chem. Int. Ed. 59, 12122 (2020).

81. Y. Du, Y. Wang, X. Hu, J. Liu, J. Diao. Single-molecule quantification of 5-methylcytosine and 5-hydroxymethyicytosine in cancer genome. View 1, e9 (2020).

80. B. Cai, J. Liu, Y. Zhao, X. Xu, B. Bu, D. Li, L. Zhang, W. Dong, B. Ji, J. Diao. Single-vesicle imaging quantifies calcium’s regulation of nanoscale vesicle clustering mediated by α-synuclein. Microsyst. Nanoeng. 6, 38 (2020).

79. C. Wang, J. Tu, S. Zhang, B. Cai, Z. Liu, S. Hou, Q. Zhong, X. Hu, W. Liu, G. Li, Z. Liu, L. He, J. Diao, Z.-J. Zhu, D. Li, C. Liu. Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly. Nat. Commun. 11, 1531 (2020).


78. H. Fang, S. Yao, Q. Chen, C. Liu, Y. Cai, S. Geng, Y. Bai, Z. Tian, A.L. Zacharias, T. Takebe, Y. Chen, Z. Guo, W. He, J. Diao. De novo-designed near-infrared nanoaggregates for super-resolution monitoring of lysosomes in cells, in whole organoids, and in vivo. ACS Nano 13, 14426 (2019).

77. Z. Wang, H. Fan, X. Hu, J. Khamo, J. Diao, K. Zhang, T.V. Pogorelov. Coaction of electrostatic and hydrophobic interactions: dynamic structural constraints on disordered TrkA juxtamembrane domain. J. Phys. Chem. B 123, 10709 (2019).

76. P. Brown, RELISH Consortium, Y. Zhou. Large expert-curated database for benchmarking document similarity detection in biomedical literature search. Database baz085 (2019).

75. N. Brose, A. Brunger, D. Cafiso, E.R. Chapman, J. Diao, F.M. Hughson, M.B. Jackson, R. Jahn, M. Lindau, C. Ma, J. Rizo, Y.-K. Shin, T.H. Söllner, L. Tamm, T.-Y. Yoon, Y. Zhang. Synaptic vesicle fusion: today and beyond. Nat. Struct. Mol. Biol. 26, 663 (2019).

74. D.-F. Ma, C.-H. Xu, W.-Q. Hou, C.-Y. Zhao, J.-B. Ma, X.-Y. Huang, Q. Jia, L. Ma, J. Diao, C. Liu, M. Li, Y. Lu. Detecting single molecule dynamics on lipid membranes with quenchers-in-a-liposome FRET. Angew. Chem. Int. Ed. 58, 5577 (2019).

73. X. Li, X. Tong, W. Lu, D. Yu, J. Diao, Q. Zhao. Label-free detection of early oligomerization of α-synuclein and its mutants A30P/E46K through solid-state nanopores. Nanoscale 11, 6480 (2019).

72. Q. Chen, X. Shao, Z. Tian, Y. Chen, P. Mondal, F. Liu, F. Wang, P. Ling, W. He, K. Zhang, Z. Guo, J. Diao. Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discovery. Nano Res. 12, 1009 (2019).

71. B. Cai, L. Yu, S.R. Sharum, K. Zhang, J. Diao. Single-vesicle measurement of protein-induced membrane tethering. Colloids Surf. B-Biointerfaces 177, 267 (2019).

70. Z. Tian, J. Gong, M. Crowe, M. Lei, D. Li, B. Ji, J. Diao. Biochemical studies of membrane fusion at the single-vesicle level. Prog. Lipid Res. 73, 92 (2019).

69. Q. Wang, X. Zhai, M. Crowe, L. Guo, Y. Li, D. Li, L. Zhang, J. Diao, B. Ji. Heterogeneous oxidization of graphene nanosheets damages membrane. Sci. China-Phys. Mech. Astron. 62, 064611 (2019).

68. J. Khamo, V. Krishnamurthy, Q. Chen, J. Diao, K. Zhang. Optogenetic delineation of receptor tyrosine kinase subcircuits during PC12 cell differentiation. Cell Chem. Biol. 26, 400 (2019).

67. Y. Hu, Z. Tian, J. Diao. Single-molecule fluorescence measurement of SNARE-mediated vesicle fusion. Methods Mol. Biol. 1860, 335 (2019).


66. Q. Chen, C. Jin, X. Shao, R. Guan, Z. Tian, C. Wang, F. Liu, P. Ling, J. Guan, L. Ji, F. Wang, H. Chao, J. Diao. Super-resolution tracking of mitochondrial dynamics with an Iridium(III) luminophore. Small 14, 1802166 (2018).

65. E. Leikina, D.G. Gamage, V. Prasad, J. Goikberg, M. Crowe, J. Diao, M.M. Kozlov, L.V. Chernomordik, D.P. Millay. Myomaker and Myomerger work independently to control distinct steps of membrane remodeling during myoblast fusion. Dev. Cell 46, 767 (2018).

64. B. Bu, M. Crowe, J. Diao, B. Ji, D. Li. Cholesterol suppresses membrane leakage by decreasing water penetrability. Soft Matter 14, 5277 (2018).

63. X. Feng, S.-J. Hsu, A. Bhattacharjee, Y. Wang, J. Diao, C.M. Price. CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells. Nat. Commun. 9, 2827 (2018).

62. Z. Tian, M. Crowe, L. Shao, P. Zhang, L. Zhang, Q. Zhao, J. Diao. Interface colloidal deposition of nanoparticle wire structures. Part. Part. Syst. Charact. 35, 1800098 (2018).

61. K. Qiu, L. Ke, X. Zhang, Y. Liu, T.W. Rees, L. Ji, J. Diao, H. Chao. Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent Iridium(III) complexes. Chem. Commun. 54, 2421 (2018).

60. M. Crowe, Z. Tian, P. Zhang, J.J. Diao. Pristine graphene modulation of vertical colloidal deposition for gold nanoparticle wires. Colloids Surf. A-Physicochem. Eng. Asp. 544, 159 (2018).


59. X. Jiang, C. Hu, K. Ferchen, J. Nie, X. Cui, C.-H. Chen, L. Cheng, Z. Zuo, W. Seibel, C. He, Y. Tang, J.R. Skibbe, M. Wunderlich, W.C. Reinhold, L. Dong, C. Shen, S. Arnovitz, B. Ulrich, J. Lu, H. Weng, R. Su, H. Huang, Y. Wang, C. Li, X. Qin, J. Mulloy, Y. Zheng, J. Diao, J. Jin, C. Li, P.P. Liu, C. He, Y. Chen, J. Chen. Targeted inhibition of STAT/TET1 axis as a potent therapeutic strategy for acute myeloid leukemia. Nat. Commun. 8, 2099 (2017).

58. A. Bhattacharjee, Y. Wang, J. Diao, C.M. Price. Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST. Nucleic Acids Res. 45, 12311 (2017).

57. C.-X. Song, S. Yin, L. Ma, A. Wheeler, Y. Chen, Y. Zhang, B. Liu, J. Xiong, W. Zhang, J. Hu, Z. Zhou, B. Dong, Z. Tian, S.S. Jeffrey, M.-S. Chua, S. So, W. Li, Y. Wei, J. Diao, D. Xie, S.R. Quake. 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages. Cell Res. 27, 1231 (2017).

56. B. Bu, X. Tong, D. Li, Y. Hu, W. He, C. Zhao, R. Hu, X. Li, Y. Shao, C. Liu, Q. Zhao, B. Ji, J. Diao. N-terminal acetylation preserves α-synuclein from oligomerization by blocking intermolecular hydrogen bonds. ACS Chem. Neurosci. 8, 2145 (2017).

55. M. Crowe, Y. Lai, Y. Wang, J. Lu, M. Zhao, Z. Tian, J. Long, P. Zhang, J. Diao. A proteoliposome method for assessing nanotoxicity on synaptic fusion and membrane integrity. Small Methods 1, 1700207, (2017). Highlighted by: Journal Cover

54. Y. Qing, Z. Tian, Y. Bi, Y. Wang, J. Long, C.-X. Song, J. Diao. Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine. Bioessays 39, 1700010 (2017).

53. Y. Hu, Y. Lai, Y. Wang, M. Zhao, Y. Zhang, M. Crowe, Z. Tian, J. Long, J. Diao. SNARE-reconstituted liposomes as controllable zeptoliter nanoreactors for macromolecules. Adv. Biosyst. 1, 1600018 (2017). Highlighted by: Advanced Science News

52. B. Bu, D. Li, J. Diao, B. Ji. Mechanics of water pore formation in lipid membrane under electric field. Acta Mech. Sin. 33, 234 (2017).

51. J. Diao, L. Li, Y. Lai, Q. Zhong. In vitro reconstitution of autophagosome-lysosome fusion. Methods Enzymol. 587, 365 (2017).


50. Y. Wang, L. Li, C. Hou, Y. Lai, J. Long, J. Liu, Q. Zhong, J. Diao. SNARE-mediated membrane fusion in autophagy. Semin. Cell Dev. Biol. 60, 97 (2016).

49. J. Gong, Y. Lai, X. Li, M. Wang, J. Leitz, Y. Hu, Y. Zhang, U.B. Choi, D. Cipriano, R.A. Pfuetzner, T.C. Südhof, X. Yang, A.T. Brunger, J. Diao. C-terminaldomain of mammalian complexin-1 localizes to highly curved membranes. Proc. Natl. Acad. Sci. USA 113, E7590 (2016).

48. Z. Tian, Y. Hu, J. Long, J. Liu, J. Diao. Single-molecule biophysical studies of neurotransmitter release. Prog. Biochem. Biophys. 43, 946 (2016). [in Chinese]

47. X. Li, R. Hu, J. Li, X. Tong, J.J. Diao, D. Yu, Q. Zhao. Non-sticky translocation of bio-molecules through Tween 20-coated solid-state nanopores in a wide pH range. Appl. Phys. Lett. 109, 143105 (2016).

46. Y. Lai, U.B. Choi, Y. Zhang, R.A. Pfuetzner, A.L. Wang, J. Diao, A.T. Brunger. N-terminaldomain of complexin independently activates calcium-triggered fusion. Proc. Natl. Acad. Sci. USA 113, E4698 (2016).

45. S. Malmersjö, S. Di Palma, J. Diao, Y. Lai, R.A. Pfuetzner, A.L. Wang, M.A. McMahon, A. Hayer, M. Porteus, B. Bodenmiller, A.T. Brunger, T. Meyer. Phosphorylation of residues inside the SNARE complex terminates secretory vesicle fusion. EMBO J. 35, 1810 (2016).

44. C. Wang, C. Zhao, D. Li, Z. Tian, Y. Lai, J. Diao, C. Liu. Versatile structures of α-synuclein. Front. Mol. Neurosci. 9, 48 (2016).

43. C.-X. Song, J. Diao, A.T. Brunger, S.R. Quake. Simultaneous single-molecule epigenetic imaging of DNA methylation andhydroxymethylation. Proc. Natl. Acad. Sci. USA 113, 4338 (2016). Highlighted by: PNAS

42. R. Hu, J. Diao, J. Li, Z. Tang, X. Li, J. Leitz, J. Long, J. Liu, D. Yu, Q. Zhao. Intrinsic and membrane-facilitated oligomerization of α-synuclein revealed by a label-free detection through solid-state nanopores. Sci. Rep. 6, 20776 (2016).

41. H. Huang, L. Yang, P. Zhang, K. Qiu, J. Huang, Y. Chen, J. Diao, J. Liu, L. Ji, J. Long, H. Chao. Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent Iridium (III) complexes. Biomaterials 83, 321 (2016).