Publications
Patents
C.-Y. Lee, J. Diao. Methods for nuclear extraction and amplification using a bio-field programmable gate array. International patent publication WO2023215298A1 (2023).
J. Diao. Epigenetic quantification using DNA hybridization-based single-molecule immunofluorescent imaging. International patent publication WO2022192510A1 (2022).
J. Diao. Super-resolution morphology-correlated detection of labile zinc. International patent publication WO2021243176A1 (2021).
J. Diao, C.-X. Song. Single-molecule epigenetic localization. International patent publication WO2020081629A1 (2020).
C.-X. Song, S.R. Quake, A.T. Brunger, J. Diao. Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation. U.S. patent publication US20170298422A1 & US20220403449A1 (2022).
M.E. Reeves, J. Diao. Method of making nanoparticle wires. U.S. patent 7829139 (2010).
Preprints
K. Qiu, W. Zou, Z. Tian, T. Huang, N-.P. Tsai, K. Zhang, J. Diao. Enhancing mitochondrial functions by optogenetic clustering. bioRxiv 2022.11.22.517578
X. Hu, W. Hao, B. Qin, Z. Tian, Z. Li, P. Hou, R. Zhao, S. Cui, J. Diao. Mechanism of duplex unwinding by coronavirus nsp13 helicases. bioRxiv 2020.08.02.233510
Representative publications in the last five years
C. Wang, C. Zhao, X. Hu, J. Qiang, Z. Liu, J. Gu, S. Zhang, D. Li, Y. Zhang, J. Burré, J. Diao, C. Liu. N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine. eLife 13, RP97228 (2024).
Q. Chen, L.-Y. Liu, Z. Tian, Z. Fang, K.-N. Wang, H. Chen, X. Shao, C. Zhang, W. Zou, F. Rowan, K. Qiu, B. Ji, J.-L. Guan, D. Li, Z.-W. Mao, J. Diao. Mitochondrial nucleoid condensates induce peripheral fission through high membrane curvature. Cell Rep. 42, 113472 (2023).
Y. Lai, C. Zhao, Z. Tian, C. Wang, J. Fan, X. Hu, J. Tu, T. Li, J. Leitz, R.A. Pfuetzner, Z. Liu, S. Zhang, Z. Su, J. Burré, D. Li, T.C. Südhof, Z.-J. Zhu, C. Liu, A.T. Brunger, J. Diao. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering. Proc. Natl. Acad. Sci. USA 120, e2310174120 (2023).
R. Chen, K. Qiu, B.K. Kundu, G. Ding, G. Han, Y. Sun, J. Diao. Quantifying cell viability through organelle ratiometric probing. Chem. Sci. 14, 10236 (2023).
R. Chen, L. Wang, G. Ding, G. Han, K. Qiu, Y. Sun, J. Diao. A constant conversion rate of endolysosomes revealed by a pH-sensitive fluorescent probe. ACS Sensors 8, 2068 (2023).
K. Qiu, W. Zou, Z. Fang, Y. Wang, S. Bell, X. Zhang, Z. Tian, X. Xu, B. Ji, D. Li, T. Huang, J. Diao. 2D MoS2 and BN nanosheets damage mitochondria through membrane penetration. ACS Nano 17, 4716 (2023).
H. Fang, L. Hu, Q. Chen, S. Geng, C. Wang, M. Hao, Z. Tian, H. Chen, L. Liu, J.-L. Guan, Y. Chen, L. Dong, Z. Guo, W. He, J. Diao. An ER-targeted “reserve-release” fluorogen for topological quantification of reticulophagy. Biomaterials 292, 121929 (2023).
K. Qiu, W. Zou, H. Fang, M. Hao, K. Mehta, Z. Tian, J.-L. Guan, K. Zhang, T. Huang, J. Diao. Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts. Nat. Commun. 13, 4303 (2022).
K. Qiu, R. Seino, G. Han, M. Ishiyama, Y. Ueno, Z. Tian, Y. Sun, J. Diao. De novo design of a membrane-anchored probe for multi-dimensional quantification of endocytic dynamics. Adv. Healthc. Mater. 11, 2102185 (2022).
Q. Chen, M. Hao, L. Wang, L. Li, Y. Chen, X. Shao, Z. Tian, R.A. Pfuetzner, Q. Zhong, A.T. Brunger, J.-L. Guan, J. Diao. Prefused lysosomes cluster on autophagosomes regulated by VAMP8. Cell Death Dis. 12, 939 (2021).
K.-N. Wang, X. Shao, Z. Tian, L.-Y. Liu, C. Zhang, C.-P. Tan, J. Zhang, P. Ling, F. Liu, Q. Chen, J. Diao, Z.-W. Mao. A continuously add-on probe reveals a nonlinear enlargement of mitochondria in light-activated oncosis. Adv. Sci. 8, 2004566 (2021).
Y. Du, Y. Lai, J. Liu, J. Diao. Epigenetic quantification of DNA 5-hydroxymethylcytosine using DNA hybridization-based single-molecule immunofluorescent imaging. Small Methods 5, 2100061 (2021).
H. Fang, S. Geng, M. Hao, Q. Chen, M. Liu, C. Liu, Z. Tian, C. Wang, T. Takebe, J.-L. Guan, Y. Chen, Z. Guo, W. He, J. Diao. Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells. Nat. Commun. 12, 109 (2021).
Q. Chen, H. Fang, X. Shao, Z. Tian, S. Geng, Y. Zhang, H. Fan, P. Xiang, J. Zhang, X. Tian, K. Zhang, W. He, Z. Guo, J. Diao. A dual-labeling molecular probe to track functional mitochondria-lysosome interactions in live cells. Nat. Commun. 11, 6290 (2020).
L.-Y. Liu, H. Fang, Q. Chen, M. H.-Y. Chan, M. Ng, K.-N. Wang, W. Liu, Z. Tian, J. Diao, Z.-W. Mao, V. W.-W. Yam. Multiple-color platinum complex with super-large Stokes shift for super-resolution imaging of autolysosome escape. Angew. Chem. Int. Ed. 59, 19229 (2020).
Q. Chen, X. Shao, M. Hao, R. Guan, Z. Tian, M. Li, C. Wang, L. Ji, H. Chao, J.-L. Guan, J. Diao. Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy. Biomaterials 250, 120059 (2020).
H. Fang, S. Yao, Q. Chen, C. Liu, Y. Cai, S. Geng, Y. Bai, Z. Tian, A.L. Zacharias, T. Takebe, Y. Chen, Z. Guo, W. He, J. Diao. De novo-designed near-infrared nanoaggregates for super-resolution monitoring of lysosomes in cells, in whole organoids, and in vivo. ACS Nano 13, 14426 (2019).
J. Khamo, V. Krishnamurthy, Q. Chen, J. Diao, K. Zhang. Optogenetic delineation of receptor tyrosine kinase subcircuits during PC12 cell differentiation. Cell Chem. Biol. 26, 400 (2019).
